Tooth is a complex natural composite, presents challenges to material scientists for the replacement of missing parts. Tooth-colored restorations have an average replacement of 5.7 years due to secondary caries occurred by the failure of tooth-restorative material bonds. This is mainly related to the inherent shortcomings of restorative materials, and limited durability of resin-dentin bonds, caused in part by water-sorption-induced hydrolysis of the hydrophilic resin components present in the adhesives, or by degradation of collagen fibrils via endogenous matrix metalloproteinases and cysteine cathepsins. Bonding to tooth structure presents a unique form of tissue engineering in which demineralized collagen matrices with the porosities of 10-30 nm wide interfibrillar spaces serves as a scaffold for the replacement material. During this process, nanometer scale biocomposites must be engineered within minutes, in situ, and are expected to last for a long period of time, which is not the case with current strategies and materials.
The research group works mainly on three main strategies to improve the durability of tooth restoration interfaces.
- To develop and model nanoscale biomimetic materials to reinforce the degraded collagen scaffolds.
- To inhibit the endogenous matrix metalloproteinase activity by means of anti-MMP compounds and monomers, which could copolymerize, stay stable as a part of hybrid layers.
- To develop strategies for biomimetic remineralization of degradaded collagen scaffolds.
Post-doc researchers : 2
PhD Students: 2
Visiting Researchers: 2
Other students: 1
Publications 2005-2010: 31
Academy of Finland
Institute of Dentistry, University of Oulu
Department of Oral Biology, Medical Collage of Georgia, Georgia, USA
Department of Biomaterials Science, Osaka University Graduate School of Dentistry, Osaka, Japan.
Department of Biomedicine, University of Trieste, Trieste, Italy
Department of Renascent Dentistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan
Arzu Tezvergil-Mutluay, Adjunct Professor, PhD, DDS
Academy Research Fellow,
Faculty of Medicine, Institute of Dentistry
Department of Prosthetic Dentistry
University of Turku
Address: Lemminkäisenkatu 2, 20520 TURKU, FINLAND
Phone Number: +358 2 333 8219
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